Perioperative Cardioprotection by Remote Ischemic Conditioning
نویسندگان
چکیده
منابع مشابه
ERICCA and RIPHeart: two nails in the coffin for cardioprotection by remote ischemic conditioning? Probably not!
Brief episodes of ischaemia/reperfusion in peripheral organs or limbs render the heart and other parenchymal organs more resistant to subsequent injury by more prolonged periods of ischaemia and reperfusion. Such remote ischaemic conditioning (RIC) has not only been demonstrated in experimental animals, but is also operative in humans. In proof-of-concept studies, RIC reduced infarct size in pa...
متن کاملRemote ischemic conditioning.
In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and render remote tissues and organs resistant to ischemia/reperfusion injury. The peripheral stimulus can be chemical, mechanical, or electrical and involves activation of peripheral sensory nerves. The signal transfer to the ...
متن کاملEndogenous cardioprotection by ischaemic postconditioning and remote conditioning.
Persistent myocardial ischaemia causes cell death if not rescued by early reperfusion. Millions of years in nature's laboratory have evolved protective responses that 'condition' the heart (and other tissues) to adapt to stressors, and these responses are applicable to the relatively new societal stress of myocardial ischaemia and reperfusion injury. Conditioning can be applied before (precondi...
متن کاملAcute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning
BACKGROUND Remote ischemic perconditioning (RIPerC) has a promising therapeutic insight to improve the prognosis of acute myocardial infarction. Chronic comorbidities such as diabetes are known to interfere with conditioning interventions by modulating cardioprotective signaling pathways, such as e.g., mTOR pathway and autophagy. However, the effect of acute hyperglycemia on RIPerC has not been...
متن کاملCirculating nitrite contributes to cardioprotection by remote ischemic preconditioning.
RATIONALE Remote ischemic preconditioning (rIPC) with short episodes of ischemia/reperfusion (I/R) of an organ remote from the heart is a powerful approach to protect against myocardial I/R injury. The signal transduction pathways for the cross talk between the remote site and the heart remain unclear in detail. OBJECTIVE To elucidate the role of circulating nitrite in cardioprotection by rIP...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2019
ISSN: 1422-0067
DOI: 10.3390/ijms20194839